The Acute Toxicity and Hematological Characterization of the Effects of Tentacle-Only Extract from the Jellyfish Cyanea capillata

Marine Drugs

Liang Xiao²  Sihua Liu²  Qian He¹  Qianqian Wang²  Xuting Ye³  Guoyan Liu²  Fei Nie²  Jie Zhao² 

[1] Department of Gynecology and Obstetrics, Shanghai Hospital, Second Military Medical University, Shanghai 200433, China; E-Mail:;Department of Chemical Defense Medicine, Faculty of Naval Medicine, Second Military Medical University, Shanghai 200433, China; E-Mails:;Department of Biophysics, School of Basic Medical, Second Military Medical University, Shanghai 200433, China; E-Mail:

关键词: jellyfish;    Cyanea capillata;    tentacle-only extract;    LD₅₀;    toxic symptom;    hematological;   

DOI  :  10.3390/md9040526

来源: mdpi

【 摘 要 】

To investigate the hematologic changes and the activities of jellyfish venoms other than hemolytic and cardiovascular toxicities, the acute toxicity of tentacle-only extract (TOE) from the jellyfish Cyanea capillata was observed in mice, and hematological indexes were examined in rats. The median lethal dose (LD₅₀) of TOE was 4.25 mg/kg, and the acute toxicity involved both heart- and nervous system-related symptoms. Arterial blood gas indexes, including pH, PCO₂, HCO₃⁻, HCO₃std, TCO₂, BEecf and BE (B), decreased significantly. PO₂ showed a slight increase, while SO₂c (%) had no change at any time. Na⁺ and Ca²⁺ decreased, but K⁺ increased. Biochemical indexes, including LDH, CK, CK-MB, ALT, AST and sCr, significantly increased. Other biochemical indexes, including BUN and hemodiastase, remained normal. Lactic acid significantly increased, while glucose, Hct% and THbc showed slight temporary increases and then returned to normal. These results on the acute toxicity and hematological changes should improve our understanding of the in vivo pathophysiological effects of TOE from C. capillata and indicate that it may also have neurotoxicity, liver toxicity and muscular toxicity in addition to hemolytic and cardiovascular toxicities, but no kidney or pancreatic toxicity.

【 授权许可】

CC BY   
© 2011 by the authors; licensee MDPI, Basel, Switzerland.