Cytotoxic Metabolites from the Soil-Derived Fungus Exophiala Pisciphila

Molecules

Cui-Cui Wang¹  Hai-Zhou Liu¹  Ming Liu¹  Yu-Yan Zhang¹  Tian-Tian Li¹ 

[1] ¹Key Laboratory of Experimental Marine Biology, Institute of Oceanology, Chinese Academy of Sciences, Qingdao 266071, China ²Graduate School of the Chinese Academy of Sciences, Beijing 100049, China

关键词: polyketide;    chromone;    indole alkaloid;    Mosher;    Exophiala pisciphila;   

DOI  :  10.3390/molecules16042796

来源: mdpi

【 摘 要 】

A new polyketide compound 1 and a new naturally occurring chromone derivative 2, along with two known indole alkaloids 3–4 were characterized from the ethyl acetate extract of a soil-derived fungal strain, Exophiala pisciphila PHF-9. The structures of compounds 1–4 were established by detailed spectroscopic analysis and comparison with literature data. The absolute configuration of 1 was determined by a modified Mosher’s method. Compound 1 exhibited moderate cytotoxicity against A-549, Hela, PANC-28 and BEL-7402 cell lines.

【 授权许可】

CC BY   
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.