Apoptosis and DNA Methylation

Cancers

Huan X. Meng³  James A. Hackett³  Colm Nestor³  Donncha S. Dunican³  Monika Madej³  James P. Reddington³  Sari Pennings¹  David J. Harrison² 

[1] Queen's Medical Research Institute, University of Edinburgh, Edinburgh EH16 4TJ, UK; E-Mail:;Breakthrough Research Unit, University of Edinburgh, Western General Hospital, Edinburgh EH4 2XU, UK; E-Mail:;MRC Human Genetics Unit, IGMM, Western General Hospital, Edinburgh EH4 2XU, UK; E-Mails:

关键词: epigenetics;    Dnmt1;    apoptosis;    Mbd4;    TDG;    demethylation;    5-hydroxymethylation;    DNA repair;   

DOI  :  10.3390/cancers3021798

来源: mdpi

【 摘 要 】

Epigenetic mechanisms assist in maintaining gene expression patterns and cellular properties in developing and adult tissues. The molecular pathology of disease states frequently includes perturbation of DNA and histone methylation patterns, which can activate apoptotic pathways associated with maintenance of genome integrity. This perspective focuses on the pathways linking DNA methyltransferases and methyl-CpG binding proteins to apoptosis, and includes new bioinformatic analyses to characterize the evolutionary origin of two G/T mismatch-specific thymine DNA glycosylases, MBD4 and TDG.

【 授权许可】

CC BY   
© 2011 by the authors; licensee MDPI, Basel, Switzerland.