Cranberry Proanthocyanidins Mediate Growth Arrest of Lung Cancer Cells through Modulation of Gene Expression and Rapid Induction of Apoptosis

Molecules

Laura A. Kresty¹  Amy B. Howell¹ 

[1] ¹Department of Epidemiology and Public Health, University of Miami Miller School of Medicine and Sylvester Cancer Center, Miami, Florida 33136, USA ²Marucci Center for Blueberry Cranberry Research, Rutgers University, Chatsworth, New Jersey 08019, USA ³Department of Pathology, The Ohio State University, Columbus, Ohio 43240, USA

关键词: cranberry;    tannins;    proanthocyanidins;    flavan-3-ols;    apoptosis;    cancer cells;    global gene expression;    cell cycle;   

DOI  :  10.3390/molecules16032375

来源: mdpi

【 摘 要 】

Cranberries are rich in bioactive constituents purported to enhance immune function, improve urinary tract health, reduce cardiovascular disease and more recently, inhibit cancer in preclinical models. However, identification of the cranberry constituents with the strongest cancer inhibitory potential and the mechanism associated with cancer inhibition by cranberries remains to be elucidated. This study investigated the ability of a proanthocyanidin rich cranberry fraction (PAC) to alter gene expression, induce apoptosis and impact the cell cycle machinery of human NCI-H460 lung cancer cells. Lung cancer is the leading cause of cancer-related deaths in the United States and five year survival rates remain poor at 16%. Thus, assessing potential inhibitors of lung cancer-linked signaling pathways is an active area of investigation.

【 授权许可】

CC BY   
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.