Imaging of Convection Enhanced Delivery of Toxins in Humans

Toxins

Ankit I. Mehta¹  Bryan D. Choi²  Raghu Raghavan²  Martin Brady²  Allan H. Friedman²  Darell D. Bigner²  Ira Pastan² 

[1] Division of Neurosurgery, Duke University Medical Center, Box 3807, Durham, NC 27710, USA;

关键词: convection enhanced delivery;    glioblastoma;    drug delivery;    imaging;   

DOI  :  10.3390/toxins3030201

来源: mdpi

【 摘 要 】

Drug delivery of immunotoxins to brain tumors circumventing the blood brain barrier is a significant challenge. Convection-enhanced delivery (CED) circumvents the blood brain barrier through direct intracerebral application using a hydrostatic pressure gradient to percolate therapeutic compounds throughout the interstitial spaces of infiltrated brain and tumors. The efficacy of CED is determined through the distribution of the therapeutic agent to the targeted region. The vast majority of patients fail to receive a significant amount of coverage of the area at risk for tumor recurrence. Understanding this challenge, it is surprising that so little work has been done to monitor the delivery of therapeutic agents using this novel approach. Here we present a review of imaging in convection enhanced delivery monitoring of toxins in humans, and discuss future challenges in the field.

【 授权许可】

CC BY   
© 2011 by the authors; licensee MDPI, Basel, Switzerland.