Circulating MicroRNAs: Potential Biomarkers for Cancer

International Journal of Molecular Sciences

De-Cai Yu¹  Qing-Guo Li¹  Xi-Wei Ding¹ 

[1] Institute of Hepatobiliary Surgery, Nanjing University, Nanjing, Jiangsu, China; E-Mails:

关键词: circulation;    microrna;    neoplasm;    biomarkers;   

DOI  :  10.3390/ijms12032055

来源: mdpi

【 摘 要 】

Cancer is the leading cause of death in the world. Development of minimally invasive biomarkers for early detection of cancer is urgently needed to reduce high morbidity and mortality associated with malignancy. MicroRNAs (miRNAs) are small regulatory RNAs that modulate the activity of specific mRNA targets and play important roles in a wide range of physiologic and pathologic processes. Recently, miRNAs were found to be dysregulated in a variety of diseases including cancer. Emerging evidence suggests that miRNAs are involved in tumor initiation and progression. Together, the different expression profiles of miRNAs in cancer, and the stability of circulating miRNAs, make them new potentially clinical biomarkers for cancer diagnosis, classification, therapeutic decisions, and prognosis.

【 授权许可】

CC BY   
© 2011 by the authors; licensee MDPI, Basel, Switzerland.