Inhibition of Inflammatory Mediators by Neobavaisoflavone in Activated RAW264.7 Macrophages

Molecules

Ewelina Szliszka¹  Dariusz Skaba¹  Zenon P. Czuba¹ 

[1] ¹Department of Microbiology and Immunology, Medical University of Silesia in Katowice, Jordana 19, 41-808 Zabrze, Poland ²Department of Conservative Dentistry and Endodontics Division of Dental Propedeutics, Medical University of Silesia in Katowice, Plac Akademicki 17, 41-902 Bytom, Poland

关键词: neobavaisoflavone;    anti-inflammatory activity;    RAW264.7 macrophages;   

DOI  :  10.3390/molecules16053701

来源: mdpi

【 摘 要 】

Flavonoids and coumarins are the major bioactive constituents identified in Psoralea corylifolia. The active fraction isolated from fruits, seeds and roots possesses antibacterial, antioxidative and immunomodulatory properties. Neobavaisoflavone is one of the flavonoids found in Psoralea corylifolia. In the present study we investigated in vitro the anti-inflammatory activity of neobavaisoflavone. Macrophages play an important role in inflammation through the release of inflammatory mediators involved in the immune response. Inappropriate and prolonged macrophage activation is largely responsible for the pathology of acute and chronic inflammatory conditions. Neobavaisoflavone significantly inhibited the production of reactive oxygen species (ROS), reactive nitrogen species (RNS) and cytokines: IL-1β, IL-6, IL-12p40, IL-12p70, TNF-α in LPS+IFN-γ– or PMA– stimulated RAW264.7 macrophages.

【 授权许可】

CC BY   
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.