Asymmetric Aldol Reactions of α,β-Unsaturated Ketoester Substrates Catalyzed by Chiral Diamines

Molecules

Sha-Sha Kan¹  Jian-Zhen Li¹  Cheng-Yan Ni¹  Quan-Zhong Liu¹ 

[1] Laboratory of Chemical Synthesis and Pollution Control, College of Chemistry and Chemical Engineering, China West Normal University, Nanchong 637009, Sichuan, China

关键词: chiral diamine;    enantioselectivity;    aldol reaction;    configuration;   

DOI  :  10.3390/molecules16053778

来源: mdpi

【 摘 要 】

Highly efficient asymmetric aldol reactions between α,β-unsaturated keto esters and acyclic ketones catalyzed by chiral diamines are reported. The corresponding products were obtained in excellent yields with excellent enantioselectivities. The absolute configuration for the product was determined by X-ray analysis. A variety of substrates were tolerable in the present catalytic system.

【 授权许可】

CC BY   
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.