d-(+)-Galactose-Conjugated Single-Walled Carbon Nanotubes as New Chemical Probes for Electrochemical Biosensors for the Cancer Marker Galectin-3

International Journal of Molecular Sciences

Young Kum Park¹  Bayarmaa Bold¹  Woo Kyung Lee¹  Min Hyon Jeon¹  Kay Hyeok An²  Seung Yol Jeong³ 

[1] Department of Nano System Engineering, Inje University, Gimhae, 612-749, Korea; E-Mails:;Carbon Valley R & D Division, Jeonju Institute of Machinery and Carbon Composites, Jeonju, 561-844, Korea; E-Mail:;Nano Carbon Materials Research Group, Korea Electrotechnology Research Institute, Changwon, 641-120, Korea; E-Mail:

关键词: biosensor;    cancer marker;    galectin-3;    galactose;    single-walled carbon nanotubes;   

DOI  :  10.3390/ijms12052946

来源: mdpi

【 摘 要 】

d-(+)-Galactose-conjugated single-walled carbon nanotubes (SWCNTs) were synthesized for use as biosensors to detect the cancer marker galectin-3. To investigate the binding of galectin-3 to the d-(+)-galactose-conjugated SWCNTs, an electrochemical biosensor was fabricated by using molybdenum electrodes. The binding affinities of the conjugated SWCNTs to galectin-3 were quantified using electrochemical sensitivity measurements based on the differences in resistance together with typical I-V characterization. The electrochemical sensitivity measurements of the d-(+)-galactose-conjugated SWCNTs differed significantly between the samples with and without galectin-3. This indicates that d-(+)-galactose-conjugated SWCNTs are potentially useful electrochemical biosensors for the detection of cancer marker galectin-3.

【 授权许可】

CC BY   
© 2011 by the authors; licensee MDPI, Basel, Switzerland.