Balticolid: A New 12-Membered Macrolide with Antiviral Activity from an Ascomycetous Fungus of Marine Origin

Marine Drugs

Muftah A. M. Shushni²  Rajinder Singh²  Renate Mentel¹ 

[1] Institute of Pharmacy, Ernst-Moritz-Arndt-University, Friedrich-Ludwig-Jahn-Strasse 17, D-17487 Greifswald, Germany; E-Mail:;Department of Pharmacognosy, Faculty of Pharmacy, Garyounis University, P.O. Box 5341, Benghazi, Libya; E-Mail:

关键词: balticolid;    antiviral;    herpes simplex virus;    marine fungi;   

DOI  :  10.3390/md9050844

来源: mdpi

【 摘 要 】

A new 12-membered macrolide, balticolid (1) was isolated from the EtOAc extract of the culture broth of fungal strain 222 belonging to the Ascomycota, which was found on driftwood collected from the coast of the Greifswalder Bodden, Baltic Sea, Germany. The structure of balticolid was determined to be (3R,11R), (4E,8E)-3-hydroxy-11-methyloxacyclododeca-4,8-diene-1,7-dione using extensive spectral data as well as the modified Mosher ester method. Balticolid (1) displayed anti-HSV-1 activity with an IC₅₀ value of 0.45 μM.

【 授权许可】

CC BY   
© 2011 by the authors; licensee MDPI, Basel, Switzerland.