X Inactivation and Progenitor Cancer Cells

Cancers

关键词: X inactivation;    Xist RNA;    chromatin;    cancer;    epigenetics;   

DOI  :  10.3390/cancers3022169

来源: mdpi

【 摘 要 】

In mammals, silencing of one of the two X chromosomes is necessary to achieve dosage compensation. The 17 kb non-coding RNA called Xist triggers X inactivation. Gene silencing by Xist can only be achieved in certain contexts such as in cells of the early embryo and in certain hematopoietic progenitors where silencing factors are present. Moreover, these epigenetic contexts are maintained in cancer progenitors in which SATB1 has been identified as a factor related to Xist-mediated chromosome silencing.

【 授权许可】

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© 2011 by the authors; licensee MDPI, Basel, Switzerland.