Gombapyrones E and F, New α-Pyrone Polyenes Produced by Streptomyces sp. KMC-002

Molecules

Hyun Bong Park¹  Hyun Ok Yang¹  Kang Ro Lee¹ 

[1] ¹Natural Medicine Center, Korea Institute of Science and Technology (KIST), Gangneung, Gangwon-do 210-340, Korea ²Natural Products Laboratory, School of Pharmacy, Sungkyunkwan University, Suwon 440-746, Korea

关键词: Streptomyces;    gombapyrone;    α-pyrone;    polyene;   

DOI  :  10.3390/molecules16053519

来源: mdpi

【 摘 要 】

Microorganism-derived polyene polyketides have been shown to display a variety of biological activities and have attracted great interest due to their structurally intriguing chemical diversity. Two new polyenes were isolated from a culture broth of Streptomyces sp. KMC-002 obtained from a soil sample in an abandoned mine. The structures of these compounds were determined to be α-pyrone-containing polyene analogues through analyses of HRFABMS, UV and NMR data, and were named Gombapyrones E (1) and F (2). Gombapyrone E (1) showed antibacterial activity against Micrococcus luteus, Enterococcus hirae, Staphylococcus aureus and MRSA.

【 授权许可】

CC BY   
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.