Bioactive Indole Derivatives from the South Pacific Marine Sponges Rhopaloeides odorabile and Hyrtios sp.

Marine Drugs

Arlette Longeon³  Brent R. Copp¹  Elodie Quévrain³  Mélanie Roué³  Betty Kientz³  Thierry Cresteil²  Sylvain Petek⁴  Cຜile Debitus⁴ 

[1] Department of Chemistry, The University of Auckland, Private Bag 92019, Auckland, New Zealand; E-Mail:;Institut de Chimie des Substances Naturelles, CNRS UPR 2301, Centre de Recherche de Gif, avenue de la Terrasse, 91198 Gif sur Yvette Cedex, France; E-Mail:;Laboratoire Molécules de Communication et Adaptation des Micro-organismes, UMR 7245 MNHN-CNRS, Muséum National d’Histoire Naturelle, 57 rue Cuvier (C.P. 54), 75005 Paris, France; E-Mails:;Centre Polynésien de Recherche sur la Biodiversité Insulaire, UMR 7138 CNRS, B.P. 529, 98713 Papeete, Tahiti, Polynésie française, France; E-Mails:

关键词: indole derivatives;    bromoindoles;    marine sponge;    Rhopaloeides odorabile;    Hyrtios sp.;    PLA₂ inhibitor;    antioxidant;    cytotoxic;   

DOI  :  10.3390/md9050879

来源: mdpi

【 摘 要 】

Indole derivatives including bromoindoles have been isolated from the South Pacific marine sponges Rhopaloeides odorabile and Hyrtios sp. Their structures were established through analysis of mass spectra and 1D and 2D NMR spectroscopic data. Their potential inhibitory phospholipase A₂ (PLA₂), antioxidant and cytotoxic activities were evaluated. The new derivative 5,6-dibromo-l-hypaphorine (9) isolated from Hyrtios sp. revealed a weak bee venom PLA₂ inhibition (IC₅₀ 0.2 mM) and a significant antioxidant activity with an Oxygen Radical Absorbance Capacity (ORAC) value of 0.22. The sesquiterpene aureol (4), also isolated from Hyrtios sp., showed the most potent antioxidant activity with an ORAC value of 0.29.

【 授权许可】

CC BY   
© 2011 by the authors; licensee MDPI, Basel, Switzerland.