State of the Art in Tumor Antigen and Biomarker Discovery

Cancers

Klervi Even-Desrumeaux¹  Daniel Baty¹ 

[1] INSERM U624, 163 avenue de Luminy, 13288 Marseille Cedex 09, France;

关键词: tumor antigen;    biomarkers;    immunotherapy;    cancer;    proteomics;   

DOI  :  10.3390/cancers3022554

来源: mdpi

【 摘 要 】

Our knowledge of tumor immunology has resulted in multiple approaches for the treatment of cancer. However, a gap between research of new tumors markers and development of immunotherapy has been established and very few markers exist that can be used for treatment. The challenge is now to discover new targets for active and passive immunotherapy. This review aims at describing recent advances in biomarkers and tumor antigen discovery in terms of antigen nature and localization, and is highlighting the most recent approaches used for their discovery including “omics” technology.

【 授权许可】

CC BY   
© 2011 by the authors; licensee MDPI, Basel, Switzerland.