Flavonoids from Praxelis clematidea R.M. King and Robinson Modulate Bacterial Drug Resistance

Molecules

Gabriela Lemos de Azevedo Maia¹  Vivyanne dos Santos Falcão-Silva¹  Pedro Gregório Vieira Aquino¹  João Xavier de Araújo-Júnior¹  Josean Fechine Tavares¹  Marcelo Sobral da Silva¹  Luis Cezar Rodrigues¹  José Pinto de Siqueira-Júnior¹ 

[1] ¹Laboratory of Pharmaceutical Technology, Federal University of Paraíba, João Pessoa, PB 58051, Brazil

关键词: Praxelis clematidea;    Asteraceae;    flavonoids;    antibacterial activity;    bacterial resistance;    efflux pump;   

DOI  :  10.3390/molecules16064828

来源: mdpi

【 摘 要 】

Chemical studies of Praxelis clematidea R.M. King & Robinson resulted in the isolation of six flavones: Apigenine, genkwanine, 7,4’-dimethylapigenin, trimethylapigenin,cirsimaritin and tetramethylscutellarein, which were tested for their toxicity against Staphylococcus aureus SA-1199B, a strain possessing the NorA efflux pump. Efflux pumps are integral proteins of the bacterial membrane and are recognized as one of the main causes of bacterial drug resistance, since they expel antibiotics from the cell. The inhibition of this transporter is one form of modulating bacterial resistance to antimicrobial drugs. The flavones tested did not show any significant antibacterial activity against the Staphylococcus aureus strain used, but were able to modulate bacterial drug resistance. This property might be related to the degree of lipophilicity of the flavones conferred by the methoxyl groups, since 4’,5,6,7 tetramethoxyflavone the most methoxylated compound, reduced the minimal inhibitory concentration of the drug 16-fold.

【 授权许可】

CC BY   
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.