Synthesis and In Vitro Protein Tyrosine Kinase Inhibitory Activity of Furan-2-yl(phenyl)methanone Derivatives

Molecules

Fei Lang Zheng¹  Shu Rong Ban¹  Xiu E Feng¹  Cheng Xiao Zhao¹  Wenhan Lin¹ 

[1] ¹School of Pharmaceutical Science, Shanxi Medical University, Taiyuan 030001, Shanxi, China ²State Key Laboratory of Natural and Biomimetic Drugs, Peking University, Beijing 100083, China

关键词: halophenols;    furan-2-yl(phenyl)methanone;    protein tyrosine kinases inhibitor;    structure-activity relationships (SAR);   

DOI  :  10.3390/molecules16064897

来源: mdpi

【 摘 要 】

A series of novel furan-2-yl(phenyl)methanone derivatives were synthesized, and their structures were established on the basis of ¹H-NMR, ¹³C-NMR and mass spectral data. All the prepared compounds were screened for their in vitro protein tyrosine kinase inhibitory activity and several new derivatives exhibited promising activity, which, in some cases, was identical to, or even better than that of genistein, a positive reference compound. The preliminary structure-activity relationships of these compounds were investigated and are discussed.

【 授权许可】

CC BY   
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.