A Novel Self-Assembled Liposome-Based Polymeric Hydrogel for Cranio-Maxillofacial Applications: Preliminary Findings

Polymers

Victor Joo¹  Thiruganesh Ramasamy¹ 

[1] Department of Bioengineering & Regenerative Medicine, Utah-Inha DDS & Advanced Therapeutics Research Center, B-404 Meet-You-All Tower, Songdo TechnoPark 7-50, Songdo-Dong, Yeonsu-Gu, Incheon, 406-840, Korea; E-Mails:

关键词: tissue engineering;    drug delivery;    dentistry;    core-shell;    liposomes;    polymer;    biomedicine;    nanoncology;    bone regeneration;    nanoshell;    amphiphilic copolymers;    nanogel;   

DOI  :  10.3390/polym3020967

来源: mdpi

【 摘 要 】

Soft nanogels are submicron-sized hydrophilic structures engineered from biocompatible polymers possessing the characteristics of nanoparticles as well as hydrogels, with a wide array of potential applications in biotechnology and biomedicine, namely, drug and protein delivery. In this work, nanogels were obtained using the physical self-assembly technique or ‘layer-by-layer’ which is based on electrostatic interactions. Liposomal vesicles were coated with alternating layers of hyaluronic acid and chitosan yielding a more viscous hydrogel formulation that previously reported core-shell nanoparticulate suspension, via simply modifying the physico-chemical characteristics of the system. Structural features, size, surface charge, stability and swelling characteristics of the nanogel were studied using scanning electron microscopy and dynamic light scattering. With a specific cranio-maxillofacial application in mind, the hydrogel was loaded with recombinant human (rh) bone morphogenetic protein-7, also known as osteogenic protein-1 or rhOP-1 and release was monitored over an extended period of 60 days. This preliminary study reports promising results on the formulation of a novel core-shell polymeric nanogel.

【 授权许可】

CC BY   
© 2011 by the authors; licensee MDPI, Basel, Switzerland.