Enantioselective Evans-Tishchenko Reduction of b-Hydroxyketone Catalyzed by Lithium Binaphtholate

Molecules

Tomonori Ichibakase¹  Masato Nakatsu¹ 

[1] Graduate School of Pharmaceutical Sciences, Kumamoto University, 5-1 Oe-honmachi, Kumamoto 862-0973, Japan

关键词: Evans-Tishchenko reduction;    lithium binaphtholate;    b-hydroxyketone;    1;    3-diol;    enantioselectivity;   

DOI  :  10.3390/molecules16065008

来源: mdpi

【 摘 要 】

Lithium diphenylbinaphtholate catalyzed the enantioselective Evans-Tishchenko reduction of achiral b-hydroxyketones to afford monoacyl-protected 1,3-diols with high stereoselectivities. In the reaction of racemic b-hydroxyketones, kinetic optical resolution occurred in a highly stereoselective manner.

【 授权许可】

CC BY   
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