Orf-I and Orf-II-Encoded Proteins in HTLV-1 Infection and Persistence

Viruses

Dustin Edwards¹  Claudio Fenizia¹  Heather Gold¹  Maria Fernanda de Castro-Amarante¹  Cody Buchmann¹  Cynthia A. Pise-Masison¹ 

[1] Animal Models and Retroviral Vaccines Section, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, MD 20892, USA

关键词: human T-cell leukemia/lymphoma virus type-1;    HTLV-1;    ORF-I;    ORF-II;    p8;    p12;    p13;    p30;   

DOI  :  10.3390/v3060861

来源: mdpi

【 摘 要 】

The 3' end of the human T-cell leukemia/lymphoma virus type-1 (HTLV-1) genome contains four overlapping open reading frames (ORF) that encode regulatory proteins. Here, we review current knowledge of HTLV-1 orf-I and orf-II protein products. Singly spliced mRNA from orf-I encodes p12, which can be proteolytically cleaved to generate p8, while differential splicing of mRNA from orf-II results in production of p13 and p30. These proteins have been demonstrated to modulate transcription, apoptosis, host cell activation and proliferation, virus infectivity and transmission, and host immune responses. Though these proteins are not essential for virus replication in vitro, p8, p12, p13, and p30 have an important role in the establishment and maintenance of HTLV-1 infection in vivo.

【 授权许可】

CC BY   
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.