Strontium Ions Substitution in Brushite Crystals: The Role of Strontium Chloride

Journal of Functional Biomaterials

Mohammad H. Alkhraisat¹  Carmen Rueda² 

[1] Departamento de Química Física II, Facultad de Farmacia, UCM, 28040 Madrid, Spain;

关键词: Brushite;    calcium phosphate cement;    strontium;    glycolic acid;   

DOI  :  10.3390/jfb2020031

来源: mdpi

【 摘 要 】

The incorporation of strontium chloride to brushite cement was successful to introduce strontium ions within the lattice of brushite crystals. The effect of strontium ions on brushite cement properties was concentration dependent; such that, the addition of 5% and 10% (w/w) SrCl₂ significantly increased the cement FST and the addition of 10% SrCl₂ decreased the cement tensile strength. Further, cement weight loss was shown to be increased by cement modification with SrCl₂. The combination of ionic substitution and the degradability of brushite cements would constitute a system for the local delivery of strontium ions in the treatment of osteoporosis.

【 授权许可】

CC BY   
© 2011 by the authors; licensee MDPI, Basel, Switzerland.