International Journal of Molecular Sciences | |
Proteomic Analysis Identified DJ-1 as a Cisplatin Resistant Marker in Non-Small Cell Lung Cancer | |
Hua-Zong Zeng4  Yi-Qing Qu2  Wen-Jun Zhang1  Bing Xiu1  An-Mei Deng3  | |
[1] Central Laboratory, Tongji Hospital of Tongji University, Tongji University, Shanghai 200065, China; E-Mails:;Department of Respiratory Medicine, Qilu Hospital, Shandong University, Jinan 250012, China; E-Mail:;Laboratory Diagnostics, Shanghai Changhai Hospital, Shanghai 200003, China;School of Life Sciences and Technology, Tongji University, Shanghai 200092, China; E-Mail: | |
关键词: non-small lung cancer; cisplatin; resistance; DJ-1; proteomics; | |
DOI : 10.3390/ijms12063489 | |
来源: mdpi | |
【 摘 要 】
The aim of study is to identify cisplatin-resistance associated biomarkers for non-small cell lung cancers (NSCLC). We use two-dimensional electrophoresis (2-DE) combined with MALDI-TOF mass spectrometry to compare the proteome between lung cancer cell line A549 and its cisplatin-resistant subline A549/DDP. Nine cisplatin resistance-related proteins were identified, and DJ-1, one of the differently expressed proteins, was selected for further validation and evaluation. Immunohistochemical results demonstrated that high expression level of DJ-1 was associated with cisplatin resistance and a predictor for poor prognosis in 67 locally advanced NSCLC patients. Furthermore,
【 授权许可】
CC BY
© 2011 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland.
【 预 览 】
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