Recombinant Cytokines from Plants

International Journal of Molecular Sciences

Agnieszka Sirko²  Tomas Vaněk¹  Anna Góra-Sochacka² 

[1] Laboratory of Plant Biotechnologies, Joint Laboratory of Institute of Experimental Botany and Institute of Crop Research, Prague, Czech Republic; E-Mail:;Institute of Biochemistry and Biophysics Polish Academy of Sciences, ul. Pawinskiego 5a, 02-106 Warsaw, Poland; E-Mails:

关键词: cytokines;    pharmaceutical proteins;    plant-based production systems;    molecular farming;    interleukins;    transgenic plants;   

DOI  :  10.3390/ijms12063536

来源: mdpi

【 摘 要 】

Plant-based platforms have been successfully applied for the last two decades for the efficient production of pharmaceutical proteins. The number of commercialized products biomanufactured in plants is, however, rather discouraging. Cytokines are small glycosylated polypeptides used in the treatment of cancer, immune disorders and various other related diseases. Because the clinical use of cytokines is limited by high production costs they are good candidates for plant-made pharmaceuticals. Several research groups explored the possibilities of cost-effective production of animal cytokines in plant systems. This review summarizes recent advances in this field.

【 授权许可】

CC BY   
© 2011 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland.