Herpesviruses and Intermediate Filaments: Close Encounters with the Third Type

Viruses

关键词: intermediate filament;    herpesvirus;    herpes simplex virus;    varicella zoster virus;    cytomegalovirus;    Epstein-Barr virus;    Kaposi’s sarcoma associated herpesvirus;    cytoskeleton;    infection;   

DOI  :  10.3390/v3071015

来源: mdpi

【 摘 要 】

Intermediate filaments (IF) are essential to maintain cellular and nuclear integrity and shape, to manage organelle distribution and motility, to control the trafficking and pH of intracellular vesicles, to prevent stress-induced cell death, and to support the correct distribution of specific proteins. Because of this, IF are likely to be targeted by a variety of pathogens, and may act in favor or against infection progress. As many IF functions remain to be identified, however, little is currently known about these interactions. Herpesviruses can infect a wide variety of cell types, and are thus bound to encounter the different types of IF expressed in each tissue. The analysis of these interrelationships can yield precious insights into how IF proteins work, and into how viruses have evolved to exploit these functions. These interactions, either known or potential, will be the focus of this review.

【 授权许可】

CC BY   
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.