期刊论文详细信息
Molecules
Licocalchone-C Extracted from Glycyrrhiza Glabra Inhibits Lipopolysaccharide-Interferon-γ Inflammation by Improving Antioxidant Conditions and Regulating Inducible Nitric Oxide Synthase Expression
Sara Franceschelli1  Mirko Pesce1  Isabella Vinciguerra1  Alessio Ferrone1  Graziano Riccioni1  Patruno Antonia1  Alfredo Grilli1  Mario Felaco1 
[1] 1Department of Human Movement Sciences, University G. D’Annunzio of Chieti, 66123, Italy 2Cardiology Unit, San Camillo de Lellis Hospital, Manfredonia, Foggia, Italy 3Department of Drug Sciences University G. D’Annunzio of Chieti, 66123, Italy
关键词: licochalcone;    inducible nitric oxide sinthase;    antioxidant properties;   
DOI  :  10.3390/molecules16075720
来源: mdpi
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【 摘 要 】

The genus Glycyrrhiza consists of about 30 species, amoung these, G. glabra is the source of several phenolic compounds, known as flavonoids, such as licoagrodin, licoagrochalcones, licoagroaurone and licochalcone C, kanzonol Y, glyinflanin B and glycyrdione A, which have shown various pharmacological activities, including antitumor, antiparasitic, antileishmanial, anti-ulcer and antioxidative effects. Among these compounds, licochalcone C was isolated but its biology has not been fully examined. In our study we reproduced an inflammatory state by treating THP-1 (human myelomonocytic leukaemia) cells with pro-inflammatory stimuli, such as LPS and IFN-γ and we investigated the possible antioxidant activity of licochalcone C at a concentration of 50 μM. Our results show that treatment with licochalcone C attenuates the LPS-IFN-γ-induced inflammatory response by significantly decreasing the expression and activity of iNOS via NFκB (nuclear factor kappa-B), by influencing extracellular O2 production, and by modulating the antioxidant network activity of SOD (superoxide dismutase), CAT (catalase) and GPx (glutathione peroxidase) activity. Based on these results we hypothesize that Licochalcone C has antioxidant properties since it reduces the production of superoxide radicals and consequently reduces the activity of iNOS.

【 授权许可】

CC BY   
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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