Pharmaceutics | |
Adenovirus Vector-Derived VA-RNA-Mediated Innate Immune Responses | |
Mitsuhiro Machitani1  Tomoko Yamaguchi2  Kahori Shimizu1  Fuminori Sakurai1  Kazufumi Katayama1  Kenji Kawabata2  | |
[1] Laboratory of Biochemistry and Molecular Biology, Graduate School of Pharmaceutical Sciences, Osaka University, 1-6, Yamadaoka, Suita, Osaka, 565-0871, Japan;Laboratory of Stem Cell Regulation, National Institute of Biomedical Innovation (NiBio), Osaka,567-0085, Japan | |
关键词: adenovirus vector; VA-RNA; gene therapy; innate immunity; | |
DOI : 10.3390/pharmaceutics3030338 | |
来源: mdpi | |
【 摘 要 】
The major limitation of the clinical use of replication-incompetent adenovirus (Ad) vectors is the interference by innate immune responses, including induction of inflammatory cytokines and interferons (IFN), following
【 授权许可】
CC BY
© 2011 by the authors; licensee MDPI, Basel, Switzerland
【 预 览 】
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