(+)-Kunstlerone, a New Antioxidant Neolignan from the Leaves of Beilschmiedia kunstleri Gamble

Molecules

Abbas Mollataghi¹  A Hamid A Hadi¹  Khalijah Awang¹  Jamaludin Mohamad¹  Marc Litaudon¹ 

[1] ¹Department of Chemistry, Faculty of Science, University of Malaya, 50603 Kuala Lumpur, Malaysia ²Institute of Biological Sciences, Faculty of Science, University of Malaya, 50603 Kuala Lumpur, Malaysia ³Centre de Recherche de Gif, Institut de Chimie des Substances Naturelles, CNRS, 1, Avenue de la Terrasse, 91198 Gif-sur-Yvette Cedex, France

关键词: Beilschmiedia kunstleri;    alkaloid;    neolignan;    lauraceae;    antioxidant;   

DOI  :  10.3390/molecules16086582

来源: mdpi

【 摘 要 】

A new neolignan, 3,4-dimethoxy-3′,4′-methylenedioxy-2,9-epoxy-6,7-cyclo-1,8-neolign-11-en-5(5H)-one, which has been named (+)-kunstlerone (1), together with six known alkaloids: (+)-norboldine (2), (+)-N-methylisococlaurine (3), (+)-cassythicine (4), (+)-laurotetanine (5), (+)-boldine (6) and (-)-pallidine (7), were isolated from the leaves of Beilschmiedia kunstleri. The structures were established through various spectroscopic methods notably 1D- and 2D-NMR, UV, IR and LCMS-IT-TOF. (+)- Kunstlerone (1) showed a strong antioxidant activity, with an SC₅₀ of 20.0 µg/mL.

【 授权许可】

CC BY   
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