Synthesis of New Riminophenazines with Pyrimidine and Pyrazine Substitution at the 2-N Position

Molecules

Gang Zhang¹  Hao Zhang¹  Xiaojian Wang¹  Chun Li¹  Haihong Huang¹ 

[1] Department of Medicinal Chemistry, Beijing Key Laboratory of Active Substance Discovery and Drugability Evaluation, Institute of Materia Medica, Peking Union Medical College and Chinese Academy of Medical Sciences, 1 Xian Nong Tan Street, Beijing 100050, China

关键词: riminophenazine;    N-arylation;    palladium catalyst;   

DOI  :  10.3390/molecules16086985

来源: mdpi

【 摘 要 】

New riminophenazines with pyrimidine and pyrazine substituents at the 2-position were successfully synthesized. The key step is the 2-N-arylation of riminophenazines with pyrimidine and pyrazine. The optimized reaction conditions involve the use of a Pd₂(dba)₃/DPPF/Cs₂CO₃/toluene combination.

【 授权许可】

CC BY   
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.