Furocoumarin Derivatives from Radix Angelicae Dahuricae and Their Effects on RXRα Transcriptional Regulation

Molecules

Dong-Ping Liu¹  Qiang Luo¹  Guang-Hui Wang¹  Yang Xu¹  Xiao-Kun Zhang¹  Quan-Cheng Chen¹ 

[1] ¹School of Pharmaceutical Sciences, Xiamen University, Xiamen 361005, China ²Sanford-Burnham Medical Research Institute, La Jolla, CA 92037, USA ^†These authors contributed equally to this work.

关键词: Radix Angelicae Dahuricae;    furocoumarins;    nuclear receptor RXRα;   

DOI  :  10.3390/molecules16086339

来源: mdpi

【 摘 要 】

A novel furocoumarin derivative named oxyalloimperatorin (1), together with seventeen furocoumarins 2–18 were isolated from the radix of Angelica dahurica. The chemical structure of new metabolite was characterized by analysis of IR, NMR, and HR-ESI-MS spectroscopic data. Among the isolated compounds, 13, 16, and 18 (each at 20 μM) could significantly promote the gene transcriptional function of nuclear receptor RXRα. While 7–9, 13, 14, and the new structure 1 (each at 20 μM) showed significant reduction in RXRα gene transcriptional activities induced by 9-cis-retinoid acid. The findings indicated that these furocoumarin skeleton derivatives might hold beneficial effects on many intractable diseases, such as cancer and metabolic diseases, due to their potential activities on regulating the transcriptional activation function of RXRα.

【 授权许可】

CC BY   
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.