A Pilot Study of the Association of Tumor Necrosis Factor Alpha Polymorphisms with Psoriatic Arthritis in the Romanian Population

International Journal of Molecular Sciences

Olivia M. Popa¹  Mihai Bojinca³  Violeta Bojinca⁴  Monica I. Dutescu⁵  Mihaela Meirosu²  Ruxandra E. Caisan⁵  Claudia Ciofu³  Constantin Bara¹ 

[1]Department of Immunology and Pathophysiology, Faculty of Medicine, University Carol Davila, Bucharest 041914, Romania

[2] E-Mails:

[3]ICA Research and Development, Bucharest 013721, Romania

[4] E-Mail:

[5]Department of Rheumatology, Faculty of Medicine, University Carol Davila, I.C. Cantacuzino Hospital, Bucharest 020475, Romania

[6] E-Mails:

[7]Department of Rheumatology, Faculty of Medicine, University Carol Davila, St. Maria Hospital, Bucharest 011172, Romania

[8] E-Mail:

[9]“Prof. Dr. C. T. Nicolau” National Institute of Blood Transfusion, Bucharest 011155, Romania

[10] E-Mails:

关键词: tumor necrosis factor alpha (TNF-alpha);    psoriatic arthritis;    single nucleotide polymorphism (SNP);    undifferentiated spondyloarthritis;   

DOI  :  10.3390/ijms12085052

来源: mdpi

【 摘 要 】

Tumor necrosis factor alpha (TNF-alpha) is an important pro-inflammatory cytokine implicated in the pathogenesis of psoriatic arthritis. We have performed a case-control association study of three TNF-alpha gene polymorphisms in a group of Romanian psoriatic arthritis patients versus ethnically matched controls. A second group of patients with undifferentiated spondyloarthritis was used in order to look for similarities in the genetic background of the two rheumatic disorders. The −857C/T polymorphism was associated with susceptibility to psoriatic arthritis in our population at the individual level (p = 0.03, OR 1.65, 95% CI 1.05–2.57) and in combined haplotypes with the −238G/A and −308G/A SNPs. Regarding the investigated polymorphisms and derived haplotypes, no potential association was found with the susceptibility to undifferentiated spondyloarthritis in Romanian patients.

【 授权许可】

CC BY   
© 2011 by the authors; licensee MDPI, Basel, Switzerland.