Chemo-Enzymatic Synthesis of a Multi-Useful Chiral Building Block Molecule for the Synthesis of Medicinal Compounds

Molecules

Toshiki Nakano¹  Yusuke Yagi¹  Mizuki Miyahara¹  Akio Kaminura¹  Motoi Kawatsura¹ 

[1]¹Department of Applied Molecular Bioscience, Graduate School of Medicine, Yamaguchi University, 2-16-1 Tokiwadai, Ube 755-8611, Japan[2] height:6px

[3]"> ²Department of Chemistry and Biotechnology, Graduate School of Engineering, Tottori University, 4-101 Koyama-minami, Tottori 680-8552, Japan

关键词: nitro alcohol;    quaternary chiral carbon;    lipase;    optically active;    synthesis;   

DOI  :  10.3390/molecules16086747

来源: mdpi

【 摘 要 】

Optical resolution of 2-methyl-2-nitrobut-3-en-1-ol has been accomplished using a “low-temperature lipase-catalyzed transesterification” carried out at −40 °C.

【 授权许可】

CC BY   
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.