Toxins | |
Impact of the Nature and Size of the Polymeric Backbone on the Ability of Heterobifunctional Ligands to Mediate Shiga Toxin and Serum Amyloid P Component Ternary Complex Formation | |
Pavel I. Kitov3  Eugenia Paszkiewicz3  Joanna M. Sadowska3  Zhicheng Deng2  Marya Ahmed2  Ravin Narain2  Thomas P. Griener1  George L. Mulvey1  Glen D. Armstrong1  | |
[1] Department of Microbiology, Immunology, and Infectious Diseases, Alberta Ingenuity Centre for Carbohydrate Science, University of Calgary, Calgary, AB, Canada T2N 4N1;Department of Chemical Engineering, University of Alberta, Edmonton AB, Canada;Department of Chemistry, Alberta Ingenuity Centre for Carbohydrate Science, University of Alberta, Edmonton AB, Canada T6G 2G2; | |
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DOI : 10.3390/toxins3091065 | |
来源: mdpi | |
【 摘 要 】
Inhibition of AB5-type bacterial toxins can be achieved by heterobifunctional ligands (BAITs) that mediate assembly of supramolecular complexes involving the toxin’s pentameric cell membrane-binding subunit and an endogenous protein, serum amyloid P component, of the innate immune system. Effective
【 授权许可】
CC BY
© 2011 by the authors; licensee MDPI, Basel, Switzerland.
【 预 览 】
Files | Size | Format | View |
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RO202003190048186ZK.pdf | 524KB | download |