Poly Lactic-co-Glycolic Acid (PLGA) as Biodegradable Controlled Drug Delivery Carrier

Polymers

Hirenkumar K. Makadia¹ 

[1] Materials Science and Engineering, University of Pennsylvania, Philadelphia, PA 19104, USA;E-Mail:

关键词: poly lactic-co-glycolic acid;    drug delivery;    PLGA degradation;    sustained release;    PLGA fabrication techniques;   

DOI  :  10.3390/polym3031377

来源: mdpi

【 摘 要 】

In past two decades poly lactic-co-glycolic acid (PLGA) has been among the most attractive polymeric candidates used to fabricate devices for drug delivery and tissue engineering applications. PLGA is biocompatible and biodegradable, exhibits a wide range of erosion times, has tunable mechanical properties and most importantly, is a FDA approved polymer. In particular, PLGA has been extensively studied for the development of devices for controlled delivery of small molecule drugs, proteins and other macromolecules in commercial use and in research. This manuscript describes the various fabrication techniques for these devices and the factors affecting their degradation and drug release.

【 授权许可】

CC BY   
© 2011 by the authors; licensee MDPI, Basel, Switzerland.