Hepatoprotective and Antioxidant Effects of Licorice Extract against CCl4-Induced Oxidative Damage in Rats

International Journal of Molecular Sciences

Hai Zhong Huo¹  Bing Wang¹  Yong Kang Liang¹  Yong Yang Bao¹ 

[1] Department of General Surgery, Ninth People’s Hospital affiliated to Shanghai Jiaotong University School of Medicine, Shanghai 200011, China;

关键词: licorice;    CCl₄;    rat;    antioxidant;    AST;    liver;   

DOI  :  10.3390/ijms12106529

来源: mdpi

【 摘 要 】

Licorice has been used in Chinese folk medicine for the treatment of various disorders. Licorice has the biological capabilities of detoxication, antioxidation, and antiinfection. In this study, we evaluated the antihepatotoxic effect of licorice aqueous extract (LE) on the carbon tetrachloride (CCl₄)-induced liver injury in a rat model. Hepatic damage, as reveled by histology and the increased activities of serum aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP) activities, and decreased levels of serum total protein (TP), albumin (Alb) and globulin (G) were induced in rats by an administration of CCl₄ at 3 mL/kg b.w. (1:1 in groundnut oil). Licorice extract significantly inhibited the elevated AST, ALP and ALT activities and the decreased TP, Alb and G levels caused by CCl₄ intoxication. It also enhanced liver super oxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GSH-Px), glutathione reductase (GR), Glutathione S-transferase (GST) activities and glutathione (GSH) level, reduced malondialdehyde (MDA) level. Licorice extract still markedly reverses the increased liver hydroxyproline and serum TNF-α levels induced by CCl₄ intoxication. The data of this study support a chemopreventive potential of licorice extract against liver oxidative injury.

【 授权许可】

CC BY   
© 2011 by the authors; licensee MDPI, Basel, Switzerland.