ATP-Dependent Chromatin Remodeling Factors and Their Roles in Affecting Nucleosome Fiber Composition

International Journal of Molecular Sciences

Paolo Piatti¹  Anette Zeilner¹ 

[1] Division of Molecular Biology, Innsbruck Medical University, Biocenter, Fritz-Pregl Strasse 3, 6020 Innsbruck, Austria;

关键词: chromatin;    histone variant;    chromatin remodeling factor;    centromere;    linker histone;    chromatin assembly;   

DOI  :  10.3390/ijms12106544

来源: mdpi

【 摘 要 】

ATP-dependent chromatin remodeling factors of the SNF2 family are key components of the cellular machineries that shape and regulate chromatin structure and function. Members of this group of proteins have broad and heterogeneous functions ranging from controlling gene activity, facilitating DNA damage repair, promoting homologous recombination to maintaining genomic stability. Several chromatin remodeling factors are critical components of nucleosome assembly processes, and recent reports have identified specific functions of distinct chromatin remodeling factors in the assembly of variant histones into chromatin. In this review we will discuss the specific roles of ATP-dependent chromatin remodeling factors in determining nucleosome composition and, thus, chromatin fiber properties.

【 授权许可】

CC BY   
© 2011 by the authors; licensee MDPI, Basel, Switzerland.