Simplified Synthesis of Isotopically Labeled 5,5-Dimethyl-pyrroline N-Oxide

Molecules

Fabian Leinisch¹  JinJie Jiang¹  Leesa J. Deterding¹ 

[1] ¹Laboratory of Toxicology and Pharmacology, National Institute of Environmental Health Sciences, National Institutes of Health, 111 TW Alexander Drive, Research Triangle Park, NC 27709, USA ²Laboratory of Structural Biology, National Institute of Environmental Health Sciences, National Institutes of Health, 111 TW Alexander Drive, Research Triangle Park, NC 27709, USA

关键词: spin trap;    isotopic labeling;    DMPO;   

DOI  :  10.3390/molecules16108428

来源: mdpi

【 摘 要 】

5,5-Dimethylpyrroline N-oxide (¹⁵N) and 5,5-di(trideuteromethyl)pyrroline N-oxide were synthesized from the respective isotopically labeled 2-nitropropane analogs obtained from the reaction of sodium nitrate with 2-halopropanes. This facile, straightforward process allows synthesizing isotopically labeled DMPO analogs in a 4-step reaction without special equipment.

【 授权许可】

CC BY   
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.