In Vitro Anti-HMPV Activity of Meroditerpenoids from Marine Alga Stypopodium zonale (Dictyotales)

Molecules

Gabriella Mendes¹  Angélica Ribeiro Soares¹  Lorena Sigiliano¹  Fernanda Machado¹  Carlos Kaiser¹  Nelilma Romeiro¹  Lísia Gestinari¹  Norma Santos¹ 

[1] ¹Laboratório Experimental de Drogas Antivirais e Citotóxicas (LEDAC), Departamento de Virologia do, Instituto de Microbiologia Paulo de Góes, Universidade Federal do Rio de Janeiro (UFRJ), CCS, Bloco I, Caixa Postal 68040, 21941-590 Rio de Janeiro, RJ, Brasil

关键词: HMPV;    alga;    antiviral;    meroditerpenoids;    Dictyotaceae;   

DOI  :  10.3390/molecules16108437

来源: mdpi

【 摘 要 】

In this paper, we evaluated the antiviral activity against HMPV replication of crude extract of the marine algae Stypopodium zonale and of two meroditerpenoids obtained from it, atomaric acid and epitaondiol, and a methyl ester derivative of atomaric acid. Their selectivity indexes were 20.78, >56.81, 49.26 and 12.82, respectively. Compared to ribavirin, the substances showed a relatively low cytotoxicity on LLC-MK2 cells, with a significant antiviral activity, inhibiting at least 90% of viral replication in vitro, which demonstrates the potential of these marine natural products to combat infections caused by HMPV in vitro.

【 授权许可】

CC BY   
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.