Regeneration Approaches for Dental Pulp and Periapical Tissues with Growth Factors, Biomaterials, and Laser Irradiation

Polymers

Chiaki Kitamura²  Tatsuji Nishihara³  Masamichi Terashita¹  Yasuhiko Tabata⁵  Eijiro Jimi⁴  Ayako Washio² 

[1] Division of Comprehensive Dentistry, Department of Clinical Communication and Practice, Kyushu Dental College, Manazuru 2-6-1, Kokurakita, Kitakyushu 803-8580, Japan;E-Mail:;Division of Pulp Biology, Operative Dentistry, and Endodontics, Department of Cariology and Periodontology, Kyushu Dental College, Manazuru 2-6-1, Kokurakita, Kitakyushu 803-8580, Japan; E-Mails:;Division of Infections and Molecular Biology, Department of Health Promotion, Kyushu Dental College, Manazuru 2-6-1, Kokurakita, Kitakyushu 803-8580, Japan;E-Mail:;Division of Molecular Signaling and Biochemistry, Department of Biosciences, Kyushu Dental College, Manazuru 2-6-1, Kokurakita, Kitakyushu 803-8580, Japan;E-Mail:;Department of Biomaterials, Institute for Frontier Medical Sciences, Kyoto University,53 Kawara-cho, Shogoin, Sakyo-ku, Kyoto 606-8507, Japan; E-Mail:

关键词: dental pulp regeneration;    regeneration of bone defects;    FGF2;    gelatin hydrogels;    laser irradiation;   

DOI  :  10.3390/polym3041776

来源: mdpi

【 摘 要 】

In current dental practice, restorative and endodontic procedures have been developed in an attempt to preserve the vitality of dental pulp after exposure to external stimuli such as caries infection. When damage to dental pulp is reversible, pulp wound healing can proceed, whereas irreversible damage induces pathological changes in dental pulp, eventually requiring its removal. Furthermore, dentists sometimes extract non-vital teeth because of severe caries progression, critical size of periapical lesion, and tooth fracture. To overcome the limitations of presently available therapies, it is important to develop regeneration therapy for dental pulp and periapical tissues. In this review, we focus on the regeneration of dental pulp and periapical tissues by application of exogenous growth factors and scaffolds, as well as low-intensity laser irradiation as an auxiliary therapy for regeneration therapy.

【 授权许可】

CC BY   
© 2011 by the authors; licensee MDPI, Basel, Switzerland.