New Polyether Triterpenoids from Laurencia viridis and Their Biological Evaluation

Marine Drugs

Francisco Cen Pacheco¹  Janny A. Villa-Pulgarin²  Faustino Mollinedo²  Manuel Norte Martín¹  José Javier Fernández¹ 

[1] University Institute for Bio-Organic Chemistry “Antonio González” (IUBO), University of La Laguna (ULL), Astrofísico Francisco Sánchez 2, La Laguna, Tenerife 38206, Spain; E-Mail:;Institute of Molecular and Cellular Biology of Cancer, Cancer Research Center, CSIC-University of Salamanca, Campus Miguel de Unamuno, Salamanca E-37007, Spain; E-Mails:

关键词: Laurencia viridis;    squalene;    polyethers;    cytotoxic activity;   

DOI  :  10.3390/md9112220

来源: mdpi

【 摘 要 】

The red seaweed Laurencia viridis is a rich source of secondary metabolites derived from squalene. New polyethers, such as iubol (2), 22-hydroxy-15(28)- dehydrovenustatriol (3), 1,2-dehydropseudodehydrothyrsiferol (4), and secodehydrothyrsiferol (5) have been isolated and characterized from this alga. The structures were determined through the interpretation of NMR spectroscopic data and the relative configuration was proposed on the basis of NOESY spectrum and biogenetic considerations. All new compounds exhibited significant cytotoxic activity against a panel of cancer cell lines.

【 授权许可】

CC BY   
© 2011 by the authors; licensee MDPI, Basel, Switzerland