Marine Drugs | |
Bacteriophages with Potential for Inactivation of Fish Pathogenic Bacteria: Survival, Host Specificity and Effect on Bacterial Community Structure | |
Carla Pereira1  Yolanda J. Silva1  Ana L. Santos1  Ângela Cunha1  Newton C. M. Gomes1  | |
[1] CESAM and Department of Biology, Campus of Santiago, University of Aveiro, 3810-193 Aveiro, Portugal; | |
关键词: phage therapy; bacteriophages; fish pathogenic bacteria; aquaculture; bacterial community structure; | |
DOI : 10.3390/md9112236 | |
来源: mdpi | |
【 摘 要 】
Phage therapy may represent a viable alternative to antibiotics to inactivate fish pathogenic bacteria. Its use, however, requires the awareness of novel kinetics phenomena not applied to conventional drug treatments. The main objective of this work was to isolate bacteriophages with potential to inactivate fish pathogenic bacteria, without major effects on the structure of natural bacterial communities of aquaculture waters. The survival was determined in marine water, through quantification by the soft agar overlay technique. The host specificity was evaluated by cross infection. The ecological impact of phage addition on the structure of the bacterial community was evaluated by DGGE of PCR amplified 16S rRNA gene fragments. The survival period varied between 12 and 91 days, with a higher viability for
【 授权许可】
CC BY
© 2011 by the authors; licensee MDPI, Basel, Switzerland
【 预 览 】
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RO202003190047610ZK.pdf | 1226KB | download |