Design, Synthesis and Antifungal/Insecticidal Evaluation of Novel Cinnamide Derivatives

Molecules

Yumei Xiao¹  Xiaoli Yang¹  Bo Li¹  Huizhu Yuan¹  Shuqing Wan¹  Yanjun Xu¹ 

[1] ¹College of Science, China Agricultural University, Beijing 100193, China ²Lab of Insect Toxicology, South China Agricultural University, Guangzhou 510642, China ³Institute of Plant Protection, Chinese Academ y of Agriculture Science, Beijing 10193, China

关键词: cinnamide;    β-phenyl ethylamine;    fungicidal activity;    insecticidal activity;   

DOI  :  10.3390/molecules16118945

来源: mdpi

【 摘 要 】

Twenty novel cinnamamide derivatives were designed and synthesized using as lead compound pyrimorph, whose morpholine moiety was replaced by β-phenylethylamine. All the compounds were characterized by their spectroscopic data. The fungicidal and insecticidal activities were also evaluated. The preliminary results showed that all the title compounds had certain fungicidal activities against seven plant pathogens at a concentration of 50 μg/mL, and compounds 11a and 11l showed inhibition ratios of up to 90% against R. solani. Most of the title compounds exhibited moderate nematicidal activities. In general, the morpholine ring may be replaced by other amines and a chlorine atom in the pyridine ring is helpful to fungicidal activity.

【 授权许可】

CC BY   
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.