Nutrients | |
Apical Localization of Zinc Transporter ZnT4 in Human Airway Epithelial Cells and Its Loss in a Murine Model of Allergic Airway Inflammation | |
Chiara Murgia1  Dion Grosser3  Ai Q. Truong-Tran3  Eugene Roscioli3  Agnes Michalczyk5  Margaret Leigh Ackland5  Meredin Stoltenberg2  Gorm Danscher2  Carol Lang3  Darryl Knight4  Giuditta Perozzi1  Richard E. Ruffin3  | |
[1] INRAN-National Research Institute on Food & Nutrition, Roma 00178, Italy;Institute of Biomedicine, Neurobiology, Aarhus University, DK-8000 Aarhus C, Denmark;Discipline of Medicine, University of Adelaide, The Queen Elizabeth Hospital, Woodville, South Australia 5011, Australia;James Hogg iCAPTURE Centre for Cardiovascular and Pulmonary Research, St Paul’s Hospital, 1081 Burrard Street, Vancouver, BC, V6Z 1Y6, Canada;Centre for Cellular and Molecular Biology, School of Biological and Chemical Sciences, Deakin University, Burwood, Victoria 3125, Australia; | |
关键词: zinc; zinc transporter; ZnT4; airway epithelium; airway inflammation; asthma; Zinquin; Se-Autometallography (Se-AMG); | |
DOI : 10.3390/nu3110910 | |
来源: mdpi | |
【 摘 要 】
The apical cytoplasm of airway epithelium (AE) contains abundant labile zinc (Zn) ions that are involved in the protection of AE from oxidants and inhaled noxious substances. A major question is how dietary Zn traffics to this compartment. In rat airways,
【 授权许可】
CC BY
© 2011 by the authors; licensee MDPI, Basel, Switzerland.
【 预 览 】
Files | Size | Format | View |
---|---|---|---|
RO202003190047460ZK.pdf | 2609KB | download |