Efficient Microwave-Assisted Synthesis of Ionic Esterified Amino Acids

Molecules

Ricardo Cerón-Camacho¹  Jorge Aburto¹  Luisa E. Montiel¹  Eugenio A. Flores¹  Frisia Cuellar¹ 

[1] Dirección de Investigación y Posgrado, Instituto Mexicano del Petróleo, Eje Central Lázaro Cárdenas 152, 07730 Mexico City, Mexico

关键词: amino acids;    esterification;    microwave;    parallel synthesis;   

DOI  :  10.3390/molecules16108733

来源: mdpi

【 摘 要 】

In this work, an efficient microwave-assisted methodology for the esterification of unprotected α-amino acids is described. Ionic esterified amino acids were synthesized in satisfactory yields in a facile one-pot solventless protocol from unprotected amino acids and alcohols under acid catalysis (MsOH or p-TsOH) to afford the pure products after a simple work-up procedure. This procedure can also be extended to the preparation of long and short chain alkyl and benzyl esters.

【 授权许可】

CC BY   
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.