Indatraline: Synthesis and Effect on the Motor Activity of Wistar Rats

Molecules

Márcia Kameyama¹  Fernanda A. Siqueira¹  Miriam Garcia-Mijares¹  Luiz F. Silva, Jr.¹ 

[1] ¹Department of Experimental Psychology, Institute of Psychology, University of São Paulo, USP, Av. Prof. Mello de Moraes, 1721, Cidade Universitária, São Paulo SP CEP 05508-030, Brazil ²Departamento de Química Fundamental, Instituto de Química, Universidade de São Paulo, CP 26077, São Paulo-SP, 05513-970, Brazil

关键词: indatraline;    cocaine abuse;    ring contraction;    motor activity;    Wistar rats;   

DOI  :  10.3390/molecules16119421

来源: mdpi

【 摘 要 】

A new approach for the synthesis of indatraline was developed using as the key step an iodine(III)-mediated ring contraction of a 1,2-dihydronaphthalene derivative. Behavioral tests were conducted to evaluate the effect of indatraline and of its precursor indanamide on the motor activity of Wistar rats. Specific indexes for ambulation, raising and stereotypy were computed one, two and three hours after i.p. drug administration. Indatraline effects on motor activity lasted for at least three hours. On the other hand, no significant differences in motor activity were observed using indanamide. The results suggest that indatraline has a long lasting effect on motor activity and add evidence in favor of the potential use of that compound as a substitute in cocaine addiction.

【 授权许可】

CC BY   
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.