Anti-Inflammatory Drug Design Using a Molecular Hybridization Approach

Pharmaceuticals

Priscila Longhin Bosquesi¹  Thais Regina Ferreira Melo¹  Ednir Oliveira Vizioli¹  Jean Leandro dos Santos¹ 

[1] Lapdesf, Laboratory of Drug Design, Department of Drugs and Medicines, School of Pharmaceutical Sciences, University of São Paulo State (UNESP), Rodovia Araraquara-Jaú, km 1, Araraquara, SP, Cep. 14.802-901, Brazil;

关键词: anti-inflammatory;    hybridization;    multiple-ligands;    mutual prodrug;   

DOI  :  10.3390/ph4111450

来源: mdpi

【 摘 要 】

The design of new drugs with better physiochemical properties, adequate absorption, distribution, metabolism, and excretion, effective pharmacologic potency and lacking toxicity remains is a challenge. Inflammation is the initial trigger of several different diseases, such as Alzheimer's disease, asthma, atherosclerosis, colitis, rheumatoid arthritis, depression, cancer; and disorders such as obesity and sexual dysfunction. Although inflammation is not the direct cause of these disorders, inflammatory processes often increase related pain and suffering. New anti-inflammatory drugs developed using molecular hybridization techniques to obtain multiple-ligand drugs can act at one or multiple targets, allowing for synergic action and minimizing toxicity. This work is a review of new anti-inflammatory drugs developed using the molecular modification approach.

【 授权许可】

CC BY   
© 2011 by the authors; licensee MDPI, Basel, Switzerland.