International Journal of Molecular Sciences | |
The Impact of Membrane Lipid Composition on Macrophage Activation in the Immune Defense against |
|
Axel Schoeniger1  Stephanie Adolph1  Herbert Fuhrmann2  | |
[1] Institute of Physiological Chemistry, Faculty of Veterinary Medicine, University of Leipzig, An den Tierkliniken 1, 04103 Leipzig, Germany; | |
关键词: RAW264.7; macrophage activation; PUFA; IL-1β; IL-6; IL-10; TNF-α; CD86; MyD88; lysozyme; | |
DOI : 10.3390/ijms12117510 | |
来源: mdpi | |
【 摘 要 】
Nutritional fatty acids are known to have an impact on membrane lipid composition of body cells, including cells of the immune system, thus providing a link between dietary fatty acid uptake, inflammation and immunity. In this study we reveal the significance of macrophage membrane lipid composition on gene expression and cytokine synthesis thereby highlighting signal transduction processes, macrophage activation as well as macrophage defense mechanisms. Using RAW264.7 macrophages as a model system, we identified polyunsaturated fatty acids (PUFA) of both the
【 授权许可】
CC BY
© 2011 by the authors; licensee MDPI, Basel, Switzerland.
【 预 览 】
Files | Size | Format | View |
---|---|---|---|
RO202003190047154ZK.pdf | 979KB | download |