Marine Drugs | |
Neoamphimedine Circumvents Metnase-Enhanced DNA Topoisomerase IIα Activity Through ATP-Competitive Inhibition | |
Jessica Ponder2  Byong Hoon Yoo2  Adedoyin D. Abraham2  Qun Li2  Amanda K. Ashley1  Courtney L. Amerin1  Qiong Zhou2  Brian G. Reid2  Philip Reigan2  Robert Hromas3  Jac A. Nickoloff1  | |
[1] Department of Environmental and Radiological Health Sciences, Colorado State University, Fort Collins, CO 80523, USA; E-Mails:;Department of Pharmaceutical Sciences, The University of Colorado Skaggs School of Pharmacy and Pharmaceutical Sciences, Anschutz Medical Campus, Aurora, CO 80045, USA; E-Mails:;Department of Medicine, University of Florida and Shands Health Care System, Gainesville, FL 32610, USA; E-Mail: | |
关键词: neoamphimedine; topoisomerase II; Metnase; cancer therapeutics; | |
DOI : 10.3390/md9112397 | |
来源: mdpi | |
【 摘 要 】
Type IIα DNA topoisomerase (TopoIIα) is among the most important clinical drug targets for the treatment of cancer. Recently, the DNA repair protein Metnase was shown to enhance TopoIIα activity and increase resistance to TopoIIα poisons. Using
【 授权许可】
CC BY
© 2011 by the authors; licensee MDPI, Basel, Switzerland
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