Trypanocidal Activity of Oxoaporphine and Pyrimidine-β-Carboline Alkaloids from the Branches of Annona foetida Mart. (Annonaceae)

Molecules

Emmanoel Vilaça Costa¹  Maria Lúcia Belém Pinheiro¹  Afonso Duarte Leão de Souza¹  Andersson Barison¹  Francinete Ramos Campos¹  Rodrigo Hinojosa Valdez¹  Tânia Ueda-Nakamura¹  Benedito Prado Dias Filho¹ 

[1] ¹LABORGANICS, Department of Chemistry, Federal University of Sergipe, 49100-000, São Cristóvão, SE, Brazil

关键词: annonaceae;    Annona foetida;    alkaloids;    oxoaporphine alkaloids;    pyrimidine-β-carboline alkaloids;    trypanocidal activity;   

DOI  :  10.3390/molecules16119714

来源: mdpi

【 摘 要 】

Phytochemical investigation of the branches of Annona foetida Mart. led to isolation from the CH₂Cl₂ extract of four alkaloids: Atherospermidine (1), described for the first time in this species, liriodenine (2), O-methylmoschatoline (3), and annomontine (4). Their chemical structures were established on the basis of spectroscopic data from IR, MS, NMR (1D and 2D), and comparison with the literature. Compounds 2–4 showed potent trypanocidal effect when evaluated against epimastigote and trypomastigote forms of Trypanosoma cruzi.

【 授权许可】

CC BY   
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