Protein Kinases and Transcription Factors Activation in Response to UV-Radiation of Skin: Implications for Carcinogenesis

International Journal of Molecular Sciences

César López-Camarillo²  Elena Arຜhaga Ocampo¹  Mavil López Casamichana²  Carlos Pérez-Plasencia³  Elizbeth Álvarez-Sánchez² 

[1]Carcinogenesis Laboratory, National Institute of Cancerology, Av. Saint Fernando 22, 14080, México

[2] E-Mail:

[3]Genomics Sciences Program, Oncogenomics and Cancer Proteomics Laboratory, University Autonomous of Mexico City, Av. San Lorenzo 290, 03100, Mexico

[4] E-Mails:

[5]Massive Sequencing Unit, National Institute of Cancerology, Av. Saint Fernando 22, 14080, México

[6] E-Mail:

关键词: ultraviolet radiation;    skin cancer;    skin photoaging;    p38;    MAPK;    JNK;    ERK1/2;    ATM;    SKR kinases;    NF-κB;    AP-1;    NRF2 transcription factors;   

DOI  :  10.3390/ijms13010142

来源: mdpi

【 摘 要 】

Solar ultraviolet (UV) radiation is an important environmental factor that leads to immune suppression, inflammation, photoaging, and skin carcinogenesis. Here, we reviewed the specific signal transduction pathways and transcription factors involved in the cellular response to UV-irradiation. Increasing experimental data supporting a role for p38, MAPK, JNK, ERK1/2, and ATM kinases in the response network to UV exposure is discussed. We also reviewed the participation of NF-κB, AP-1, and NRF2 transcription factors in the control of gene expression after UV-irradiation. In addition, we discussed the promising chemotherapeutic intervention of transcription factors signaling by natural compounds. Finally, we focused on the review of data emerging from the use of DNA microarray technology to determine changes in global gene expression in keratinocytes and melanocytes in response to UV treatment. Efforts to obtain a comprehensive portrait of the transcriptional events regulating photodamage of intact human epidermis after UV exposure reveals the existence of novel factors participating in UV-induced cell death. Progress in understanding the multitude of mechanisms induced by UV-irradiation could lead to the potential use of protein kinases and novel proteins as specific targets for the prevention and control of skin cancer.

【 授权许可】

CC BY   
© 2012 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland.