Neonaucline, a New Indole Alkaloid from the Leaves of Ochreinauclea maingayii (Hook. f.) Ridsd. (Rubiaceae)

Molecules

Mat Ropi Mukhtar¹  Norfaizah Osman¹  Khalijah Awang¹  Hazrina Hazni¹  Ahmad Kaleem Qureshi¹  A. Hamid A. Hadi¹  Kazuma Zaima¹  Hiroshi Morita¹ 

[1] ¹Department of Chemistry, Faculty of Science, University of Malaya, 50603 Kuala Lumpur, Malaysia ²Faculty of Pharmaceutical Sciences, Hoshi University, Shinagawa-ku, Tokyo 142-8501, Japan ³Institut de Chimie de la Substances Naturelles, Centre Nationale de la Recherches Scientifique, 91198, Gif-sur Yvette, Cedex, France

关键词: Ochreinauclea maingayii;    neonaucline;    nauledine;    cadamine;    Rubiaceae;    alkaloid;   

DOI  :  10.3390/molecules17010267

来源: mdpi

【 摘 要 】

A new indole alkaloid; neonaucline (1), along with six known compounds–Cadamine (2), naucledine (3), harmane, benzamide, cinnamide and blumenol A–were isolated from the leaves of Ochreinauclea maingayii (Rubiaceae). In addition to that of compound 1, ¹³C-NMR data of cadamine (2) and naucledine (3) were also reported. Structural elucidations of these alkaloids were performed using spectroscopic methods especially 1D- and 2D-NMR, IR, UV and LCMS-IT-TOF. The excellent vasorelaxant activity on isolated rat aorta was observed for the alkaloids 1–3 after injection of each sample at 1 × 10⁻⁵ M.

【 授权许可】

CC BY   
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