NF-kappaB in Lung Tumorigenesis

Cancers

Zhenjian Cai¹  Kam-Meng Tchou-Wong¹ 

[1] Division of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, New York University School of Medicine, 462 First Avenue, NBV 7N24, New York, NY 10016, USA; E-Mails:

关键词: NF-kappaB;    lung cancer;    tumorigenesis;    tumor initiation;    tumor promotion;    tumor progression;   

DOI  :  10.3390/cancers3044258

来源: mdpi

【 摘 要 】

The development of lung cancer in humans can be divided into three steps initiation, promotion and progression. This process is driven by alterations in related signal transduction pathways. These pathways signal the aberrant activation of NF-kappaB, a transcription factor that regulates the expression of genes important for lung tumorigenesis. Our current knowledge about the role of the NF-kappaB signaling pathway in the development of lung cancer has been bolstered by animal models demonstrating the connection between K-ras and tobacco induced lung transformation with NF-kappaB. Activation of downstream genes leads to cell proliferation, inhibition of apoptosis, angiogenesis, inflammation, invasion, and metastasis.

【 授权许可】

CC BY   
© 2011 by the authors; licensee MDPI, Basel, Switzerland.